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Episode 2

Researcher with Bipolar Shatters Stigma

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Researcher with Bipolar Shatters Stigma

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About the host

Bret Scher, MD

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret is the host of the Metabolic Mind YouTube channel and podcast. He is a board-certified cardiologist, lipidologist, and leading expert in therapeutic uses of metabolic therapies, including ketogenic diets. Prior to joining Baszucki Group, Bret was the medical director at DietDoctor.com, an online platform promoting improving metabolic health through low-carb nutrition, where he was a content creator and medical reviewer. Earlier in his career, he worked as a cardiologist in San Diego. Bret has spent most of his 20-year career as a preventive cardiologist, helping people improve their metabolic health and preventing heart disease using low-carb nutrition and lifestyle interventions. His deep passion for educating the public about the benefits of metabolic therapies grew from his experience with the prevailing medical teaching, which frequently misrepresents nutrition science and undervalues metabolic health. Bret received an MD from The Ohio State University College of Medicine and a BS in Biology from Stanford University. He grew up in San Diego and began competing in triathlons at an early age, which helped fuel his love of health and fitness. He continues to enjoy spending time outdoors mountain biking, swimming, hiking, and playing baseball with his two boys.
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About the guest

Iain Campbell, PhD

Iain Campbell, PhD

Research Fellow in Metabolic Psychiatry at the University of Edinburgh

Iain Campbell, PhD

Research Fellow in Metabolic Psychiatry at the University of Edinburgh

Dr. Campbell’s pioneering work at the Metabolic Psychiatry Hub is advancing the field of metabolic psychiatry by integrating research and treatment, demonstrating how ketogenic therapy can be a powerful tool for addressing both metabolic and mental health in the treatment of bipolar disorder.
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Key Highlights

  • The episode introduces Dr. Iain Campbell, a bipolar disorder researcher at the University of Edinburgh who also lives with bipolar disorder, giving him a rare blend of scientific insight and lived experience that deeply informs his advocacy and research.
  • Iain explains how traditional bipolar medications—especially anticonvulsants—are lifesaving in acute mania but often suppress overall brain function, leaving many people unable to thrive. His personal transformation began when a ketogenic diet unexpectedly restored his mental energy, clarity, and emotional resilience.
  • He shares openly about the stigma of bipolar disorder and the real social and professional risks of going public. He chooses to speak out because he feels a moral responsibility to help others after experiencing a life-changing improvement through metabolic therapy.
  • Iain describes his ongoing work: a pilot clinical trial funded by the Baszucki Brain Research Fund studying the ketogenic diet for bipolar disorder, using MRI imaging, metabolomics, and symptom tracking to understand how ketosis influences brain energy, mood stability, and underlying biological mechanisms.
  • He discusses the promise of metabolic psychiatry—including ketogenic diets, metformin, and other metabolic interventions—and how these approaches may address bipolar disorder at a cellular energy level rather than merely balancing neurotransmitters. He also reflects on hypomania, creativity, and the challenge of maintaining safety while allowing individuals to live meaningful, energized lives.

Transcript

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