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Episode 107

Can Ketogenic Therapy Put OCD Into Remission?

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Can Ketogenic Therapy Put OCD Into Remission?

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About the host

Bret Scher, MD

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret is the host of the Metabolic Mind YouTube channel and podcast. He is a board-certified cardiologist, lipidologist, and leading expert in therapeutic uses of metabolic therapies, including ketogenic diets. Prior to joining Baszucki Group, Bret was the medical director at DietDoctor.com, an online platform promoting improving metabolic health through low-carb nutrition, where he was a content creator and medical reviewer. Earlier in his career, he worked as a cardiologist in San Diego. Bret has spent most of his 20-year career as a preventive cardiologist, helping people improve their metabolic health and preventing heart disease using low-carb nutrition and lifestyle interventions. His deep passion for educating the public about the benefits of metabolic therapies grew from his experience with the prevailing medical teaching, which frequently misrepresents nutrition science and undervalues metabolic health. Bret received an MD from The Ohio State University College of Medicine and a BS in Biology from Stanford University. He grew up in San Diego and began competing in triathlons at an early age, which helped fuel his love of health and fitness. He continues to enjoy spending time outdoors mountain biking, swimming, hiking, and playing baseball with his two boys.
Learn more about Bret

About the guest

Chris Palmer, MD

Chris Palmer, MD

Psychiatrist

Chris Palmer, MD

Psychiatrist

Dr. Chris Palmer is the founder and director of the Metabolic and Mental Health Program at McLean Hospital and an assistant professor of psychiatry at Harvard Medical School. As a practicing psychiatrist for almost three decades, he uses metabolic and ketogenic therapies to treat patients with severe mental illness. In 2022, Dr. Palmer published Brain Energy, which explores a new hypothesis of energy and mitochondrial dysfunction as an underlying cause of mental illness.
Learn more about Chris

About the guest

Aaron John MacDonald

Aaron John MacDonald

Member of McLean Hospital’s Metabolic and Mental Health Program and the Brain Energy team

Aaron John MacDonald

Member of McLean Hospital’s Metabolic and Mental Health Program and the Brain Energy team

Aaron MacDonald is a member of the Metabolic and Mental Health Program at McLean Hospital. His work focuses on the intersection of psychiatry, neuroscience, and metabolism, and he is particularly interested in the role of diet, mitochondrial function, and metabolic therapies in mental health. He holds a Bachelor of Science in Biological Sciences from Clemson University and is actively involved in research exploring novel approaches to treating mental illness.
Learn more about Aaron

About the host

Bret Scher, MD

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret is the host of the Metabolic Mind YouTube channel and podcast. He is a board-certified cardiologist, lipidologist, and leading expert in therapeutic uses of metabolic therapies, including ketogenic diets. Prior to joining Baszucki Group, Bret was the medical director at DietDoctor.com, an online platform promoting improving metabolic health through low-carb nutrition, where he was a content creator and medical reviewer. Earlier in his career, he worked as a cardiologist in San Diego. Bret has spent most of his 20-year career as a preventive cardiologist, helping people improve their metabolic health and preventing heart disease using low-carb nutrition and lifestyle interventions. His deep passion for educating the public about the benefits of metabolic therapies grew from his experience with the prevailing medical teaching, which frequently misrepresents nutrition science and undervalues metabolic health. Bret received an MD from The Ohio State University College of Medicine and a BS in Biology from Stanford University. He grew up in San Diego and began competing in triathlons at an early age, which helped fuel his love of health and fitness. He continues to enjoy spending time outdoors mountain biking, swimming, hiking, and playing baseball with his two boys.
Learn more about Bret

About the guest

Chris Palmer, MD

Chris Palmer, MD

Psychiatrist

Chris Palmer, MD

Psychiatrist

Dr. Chris Palmer is the founder and director of the Metabolic and Mental Health Program at McLean Hospital and an assistant professor of psychiatry at Harvard Medical School. As a practicing psychiatrist for almost three decades, he uses metabolic and ketogenic therapies to treat patients with severe mental illness. In 2022, Dr. Palmer published Brain Energy, which explores a new hypothesis of energy and mitochondrial dysfunction as an underlying cause of mental illness.
Learn more about Chris

About the guest

Aaron John MacDonald

Aaron John MacDonald

Member of McLean Hospital’s Metabolic and Mental Health Program and the Brain Energy team

Aaron John MacDonald

Member of McLean Hospital’s Metabolic and Mental Health Program and the Brain Energy team

Aaron MacDonald is a member of the Metabolic and Mental Health Program at McLean Hospital. His work focuses on the intersection of psychiatry, neuroscience, and metabolism, and he is particularly interested in the role of diet, mitochondrial function, and metabolic therapies in mental health. He holds a Bachelor of Science in Biological Sciences from Clemson University and is actively involved in research exploring novel approaches to treating mental illness.
Learn more about Aaron

Key Highlights

  • A published case series documents three individuals with severe, treatment-resistant OCD whose symptoms dramatically improved or went into remission with ketogenic therapy, showing reproducible “on-off” diet effects.
  • Cases illustrate different timelines: two patients experienced near-resolution of symptoms within two weeks of achieving ketosis, while a third required nearly a year — underscoring the importance of persistence and individualized response.
  • Mechanistically, metabolic dysfunction may underlie OCD, with ketogenic diets enhancing brain energy metabolism and neurotransmitter regulation; overlapping pathways could explain benefits across multiple psychiatric diagnoses.
  • All three patients had prior exposure to standard treatments (SSRIs, antipsychotics, CBT/ERP) without adequate relief or with intolerable side effects; ketosis offered meaningful symptom reduction and improved quality of life.
  • Authors stress the need for randomized controlled trials, while urging clinicians to consider ketogenic therapy as an option for patients who have exhausted conventional treatments — always under medical supervision.

Transcript

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