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Episode 146

Metabolic Mailbag: Ketone Plateaus, Sleep Issues, Fat Intake, and More

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Metabolic Mailbag: Ketone Plateaus, Sleep Issues, Fat Intake, and More

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About the host

Bret Scher, MD

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret is the host of the Metabolic Mind YouTube channel and podcast. He is a board-certified cardiologist, lipidologist, and leading expert in therapeutic uses of metabolic therapies, including ketogenic diets. Prior to joining Baszucki Group, Bret was the medical director at DietDoctor.com, an online platform promoting improving metabolic health through low-carb nutrition, where he was a content creator and medical reviewer. Earlier in his career, he worked as a cardiologist in San Diego. Bret has spent most of his 20-year career as a preventive cardiologist, helping people improve their metabolic health and preventing heart disease using low-carb nutrition and lifestyle interventions. His deep passion for educating the public about the benefits of metabolic therapies grew from his experience with the prevailing medical teaching, which frequently misrepresents nutrition science and undervalues metabolic health. Bret received an MD from The Ohio State University College of Medicine and a BS in Biology from Stanford University. He grew up in San Diego and began competing in triathlons at an early age, which helped fuel his love of health and fitness. He continues to enjoy spending time outdoors mountain biking, swimming, hiking, and playing baseball with his two boys.
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About the guest

Georgia Ede, MD

Georgia Ede, MD

Psychiatrist

Georgia Ede, MD

Psychiatrist

Dr. Georgia Ede is a Harvard-trained psychiatrist specializing in nutritional and metabolic psychiatry. She has used ketogenic diets to help her patients for over two decades. She created the first CME course training physicians in the use of ketogenic therapy as mental illness treatment. She educates the public about nutrition science, metabolism, and mental health through her international speaking engagements, website, and her first book: Change Your Diet, Change Your Mind.
Learn more about Georgia

Key Highlights

  • Ketone plateaus can be normal and do not always require action. As people become more fat adapted, their bodies may produce only the ketones they need, resulting in lower blood readings. If symptoms such as depression remain improved, there is usually no need to chase higher numbers.
  • If benefits begin to fade, there are practical ways to increase ketones, including tightening carbohydrate intake, avoiding excess protein, incorporating exercise, and using intermittent fasting. The focus should remain on symptom improvement rather than a specific ketone target.
  • Endogenous and exogenous ketones are not equivalent. Supplements can temporarily raise blood ketone levels, but they do not replicate the full metabolic shift of lowering glucose and insulin that comes from producing ketones naturally through diet.
  • Total versus net carbs depends on the food source. For whole foods, subtracting natural fiber can be reasonable. For packaged keto products, counting total carbohydrates is safer because added fibers and sugar alcohols can still raise glucose and insulin in some people.
  • Keto related insomnia is often temporary but may require troubleshooting. Common contributors include rapid carbohydrate reduction, electrolyte imbalance, increased sensitivity to caffeine or alcohol, and medication adjustments. Most people find sleep improves after the adaptation period.

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