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Episode 141

Go Slowly: A Beginners Guide to Psychiatric Drug Tapering (Part 2)

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Go Slowly: A Beginners Guide to Psychiatric Drug Tapering (Part 2)

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About the host

Bret Scher, MD

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret is the host of the Metabolic Mind YouTube channel and podcast. He is a board-certified cardiologist, lipidologist, and leading expert in therapeutic uses of metabolic therapies, including ketogenic diets. Prior to joining Baszucki Group, Bret was the medical director at DietDoctor.com, an online platform promoting improving metabolic health through low-carb nutrition, where he was a content creator and medical reviewer. Earlier in his career, he worked as a cardiologist in San Diego. Bret has spent most of his 20-year career as a preventive cardiologist, helping people improve their metabolic health and preventing heart disease using low-carb nutrition and lifestyle interventions. His deep passion for educating the public about the benefits of metabolic therapies grew from his experience with the prevailing medical teaching, which frequently misrepresents nutrition science and undervalues metabolic health. Bret received an MD from The Ohio State University College of Medicine and a BS in Biology from Stanford University. He grew up in San Diego and began competing in triathlons at an early age, which helped fuel his love of health and fitness. He continues to enjoy spending time outdoors mountain biking, swimming, hiking, and playing baseball with his two boys.
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About the guest

Georgia Ede, MD

Georgia Ede, MD

Psychiatrist

Georgia Ede, MD

Psychiatrist

Dr. Georgia Ede is a Harvard-trained psychiatrist specializing in nutritional and metabolic psychiatry. She has used ketogenic diets to help her patients for over two decades. She created the first CME course training physicians in the use of ketogenic therapy as mental illness treatment. She educates the public about nutrition science, metabolism, and mental health through her international speaking engagements, website, and her first book: Change Your Diet, Change Your Mind.
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Key Highlights

  • Safe tapering is complex and commonly misunderstood, especially for people who feel better after lifestyle changes like ketogenic therapy and want to reduce medications, because many prescribers are not well trained in tapering and abrupt or overly fast reductions can cause harm.
  • Three core tapering principles guide safer outcomes: personalization (tailored to the individual), patience (often a long process), and professional support (close supervision and guidance).
  • The most common tapering mistakes include stopping cold turkey, cutting doses in big linear steps, and taking medications every other day or a few times a week, which can create unstable drug levels and provoke significant withdrawal symptoms.
  • Hyperbolic tapering helps explain why “the last little bit” can be the hardest: the brain reacts to percentage changes, not milligrams, so equal milligram cuts become progressively larger percentage drops as the dose gets lower, often requiring slower reductions near the end.
  • Withdrawal can escalate if ignored: acute withdrawal soon after a dose drop may improve quickly if the dose is raised back promptly, but pushing through severe withdrawal can increase the risk of protracted withdrawal that may last months to years, where time and brain-supportive lifestyle foundations (sleep, stress reduction, substance-free living, nutrition, exercise, therapy) become central to recovery.

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