Linking Mitochondrial Dysfunction, Neurotransmitter, and Neural Network Abnormalities and Mania: Elucidating Neurobiological Mechanisms of the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder

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Reviews

Linking Mitochondrial Dysfunction, Neurotransmitter, and Neural Network Abnormalities and Mania: Elucidating Neurobiological Mechanisms of the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder

This review paper describes recent findings, highlighting 2 types of neurobiological abnormalities in BD: 1) mitochondrial dysfunction and 2) neurotransmitter and neural network functional abnormalities.

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Reviews

Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar DepressionMedically Supervised Ketogenic Diet as an Adjunctive Treatment for Moderate to Severe Depression: A Pilot Study

Lamotrigine treats both epilepsy and bipolar disorder via shared neurobiology. This review explores whether therapeutic ketosis may synergistically enhance mood stabilization and metabolic health.

Reviews

The Ketogenic Diet: An Anti-InflammatoryTreatment for Schizophrenia?

This review describes preclinical and clinical work that suggests ketogenic therapy may improve schizophrenia symptoms by modulating inflammation, cellular metabolism, and epigenetics. Current evidence is preliminary and requires...

Reviews

Ketogenic Diets and Depression and Anxiety

This review and meta-analysis of 50 studies found that ketogenic diets modestly improved depressive symptoms, particularly when ketone levels are monitored, but there is inconclusive evidence for anxiety.