Science: Research Database

A collection of research exploring the potential of ketogenic metabolic therapy as a novel, low-risk intervention for a wide range of neuropsychiatric conditions.

A case series of three individuals with obsessive-compulsive disorder (OCD) who achieve medication-free remission and a 90.5% reduction in symptoms after adopting a ketogenic diet.

A case study describing the first clinical application of a ketogenic diet in adult OCD with ulcerative colitis (UC) resulting in complete remission of OCD, clinical remission of UC, and improved metabolic health.

A case series of two individuals who experienced full remission of psychotic and mood symptoms after implementing ketogenic metabolic therapy.

A ketogenic diet may benefit individuals with autism spectrum disorder by addressing underlying metabolic and neuroprotective mechanisms.

A clinical trial protocol to investigate whether a ketogenic diet can reduce psychiatric and metabolic symptoms in individuals with bipolar disorder, schizophrenia, and schizoaffective disorder by comparing it…

A case study about how ketogenic therapy improved treatment-resistant depressive symptoms in a patient with bipolar disorder, leading to a stabilized mood, enhanced quality of life, and reduced medication…

Disruptions in metabolic pathways are linked to serious mental illness and suggest that ketogenic interventions may help restore metabolic balance based on gene expression data analysis.

Analysis demonstrating that in lived experience accounts of ketogenic therapy for depressive symptoms, pros outweigh cons for participants.

Review of evidence about how ketogenic diets may improve mood disorders by targeting metabolic dysfunctions, including mitochondrial issues, inflammation, oxidative stress, and insulin resistance, as explored in recent…

A 4-month clinical trial at Stanford of ketogenic diet for serious mental illness showed promising preliminary results indicating remission of bipolar disorder and schizophrenia in participants who adhered…

A case series of three adults who achieve complete remission of major depression and generalized anxiety disorder with a ketogenic dietary intervention.

A clinical trial paper demonstrating the  safety and efficacy of using ketogenic therapy in bipolar disorder.

This study looked at people with both type 2 diabetes and depression, finding that standard treatments might not work as well for them. It tested whether adding a…

Researchers at Harvard published this case series suggesting a ketogenic diet may be useful for some patients with anorexia nervosa.

Drs. Shebani Sethi and Judy Ford call for more clinical trials to address the potential beneficial effects of the ketogenic diet in people with serious mental illness.

A small pilot trial demonstrated safety and efficacy for adults with chronic psychopathology and supports specific neurobiological mechanisms that can be normalized using therapeutic ketogenic diet and ketamine.

Dr. Albert Danan showed that in a French cohort of treatment-resistant inpatients, all experienced weight loss and psychiatric symptom reduction, with nearly half no longer meeting criteria for…

Dr. Cynthia Calkin and colleagues demonstrate that improving insulin sensitivity in treatment-resistant bipolar depression led to remission after decades of illness.

Drs. Harry and Iain Campbell suggest that mitochondrial dysfunction in bipolar disorder likely stems from issues with the Pyruvate Dehydrogenase Complex (PDC), leading to reduced energy production (ATP)….

A commentary reviewing the emerging evidence supporting the use of nutritional ketosis as a treatment for serious mental illness.