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First Ever Peer-Reviewed Trial of Ketogenic Diet for Depression Shows Robust Improvement in College Students’ Symptoms

New findings published in Translational Psychiatry highlight ketogenic therapy as a feasible treatment for depression in young adults.

Diagnosis

Major Depressive Disorder

Principal Investigator

Jeff Volek, PhD, RD

Institution

The Ohio State University

Location

Columbus, Ohio

The study is the first in the history of psychiatric research to test a ketogenic diet as a treatment for major depressive disorder. These promising preliminary results in a young adult population demonstrate improvements in psychiatric and metabolic health.

The KIND Study: Diet Improves Depression in College Students

For young adults struggling with depression, this study highlights that ketogenic therapy is a viable option.

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Second week, going into the third, my depression symptoms were gone.

There is a lot of beauty in this world, and sometimes all it takes is putting something different in your body.


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A Pilot Study of Ketogenic Therapy in Major Depressive Disorder: Clinical and Metabolic Findings

This pilot study investigated the feasibility and safety of ketogenic therapy as an adjunctive treatment for young adults (18-30 years old) with major depressive disorder (MDD) receiving standard care (counseling and/or medication).

Sixteen participants achieved and maintained ketosis for the majority of the tested days over 10-12 weeks. Within 2-6 weeks of the start of the trials, participants showed robust improvements of depressive symptoms (PHQ-9, HDRS) and well-being (WHO-5). This timing is consistent with the time to reach ketosis. These positive psychological effects were sustained throughout the trial period. Improvements were also observed in physical measures, including body mass and fat mass, and metabolic measures, including decreased leptin and increased BDNF. These results suggest improvements in energy use. Participants also showed improvements in some cognitive tests.

Overall, these results show promise for the potential of ketogenic therapy as a safe and feasible therapy for young adults with depression.


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