Dr. Cynthia Calkin and colleagues demonstrate that improving insulin sensitivity in treatment-resistant bipolar depression led to remission after decades of illness.
The Cholesterol Code is now streaming. Watch the documentary.
Treating Insulin Resistance With Metformin as a Strategy to Improve Clinical Outcomes in Treatment-Resistant Bipolar Depression
Dr. Cynthia Calkin and colleagues demonstrate that improving insulin sensitivity in treatment-resistant bipolar depression led to remission after decades of illness.
In a 6-week randomized trial, adults with treatment-resistant depression had modest depressive symptom improvements on the ketogenic diet.
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In a virtual 14-week pilot, participants maintained nutritional ketosis with high retention and tolerability, alongside significant reductions in depression, anxiety, and anhedonia.
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A pilot study of college students found a ketogenic diet was feasible alongside standard care and associated with ~70% depression symptom reduction, improved well-being and cognition, and weight...
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