background logo image

Episode 204

GLP-1s, Weight Loss, and the Stigma We Don’t Talk About

Listen, Watch & Subscribe on:

Watch

GLP-1s, Weight Loss, and the Stigma We Don’t Talk About

Listen

About the host

Bret Scher, MD

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret is the host of the Metabolic Mind YouTube channel and podcast. He is a board-certified cardiologist, lipidologist, and leading expert in therapeutic uses of metabolic therapies, including ketogenic diets. Prior to joining Baszucki Group, Bret was the medical director at DietDoctor.com, an online platform promoting improving metabolic health through low-carb nutrition, where he was a content creator and medical reviewer. Earlier in his career, he worked as a cardiologist in San Diego. Bret has spent most of his 20-year career as a preventive cardiologist, helping people improve their metabolic health and preventing heart disease using low-carb nutrition and lifestyle interventions. His deep passion for educating the public about the benefits of metabolic therapies grew from his experience with the prevailing medical teaching, which frequently misrepresents nutrition science and undervalues metabolic health. Bret received an MD from The Ohio State University College of Medicine and a BS in Biology from Stanford University. He grew up in San Diego and began competing in triathlons at an early age, which helped fuel his love of health and fitness. He continues to enjoy spending time outdoors mountain biking, swimming, hiking, and playing baseball with his two boys.
Learn more about Bret

Bret Scher, MD

Medical Director, Metabolic Mind and Baszucki Group

Bret is the host of the Metabolic Mind YouTube channel and podcast. He is a board-certified cardiologist, lipidologist, and leading expert in therapeutic uses of metabolic therapies, including ketogenic diets. Prior to joining Baszucki Group, Bret was the medical director at DietDoctor.com, an online platform promoting improving metabolic health through low-carb nutrition, where he was a content creator and medical reviewer. Earlier in his career, he worked as a cardiologist in San Diego. Bret has spent most of his 20-year career as a preventive cardiologist, helping people improve their metabolic health and preventing heart disease using low-carb nutrition and lifestyle interventions. His deep passion for educating the public about the benefits of metabolic therapies grew from his experience with the prevailing medical teaching, which frequently misrepresents nutrition science and undervalues metabolic health. Bret received an MD from The Ohio State University College of Medicine and a BS in Biology from Stanford University. He grew up in San Diego and began competing in triathlons at an early age, which helped fuel his love of health and fitness. He continues to enjoy spending time outdoors mountain biking, swimming, hiking, and playing baseball with his two boys.
Learn more about Bret

Key Highlights

  • A New York Post report found that people losing weight with medications like Ozempic or Wegovy face more social stigma than those who don’t lose weight at all, prompting Dr. Bret Scher to examine his own past criticism of GLP-1 overuse.
  • He clarifies his criticism has never targeted patients choosing to use these medications, but rather clinicians who prescribe GLP-1s without equally emphasizing protein intake, resistance training, and reducing processed carbs.
  • Both common outcomes, stopping the medication and regaining weight, or staying on it long-term and becoming dependent, are framed as failing to represent true clinical success for the patient.
  • Scher argues the medical system needs to hold prescribers accountable for pairing GLP-1s with genuine lifestyle support rather than treating the drug as a standalone quick fix.
  • He calls for changing the broader conversation to support and celebrate individual weight loss choices while demanding more comprehensive, long-term-focused care from the medical community.

Transcript

Listen, Watch & Subscribe on:

You May Also Be Interested In:

Find Your Keto
Resources

Find Your Keto

Explore metabolic therapies with Steven who put his bipolar 2 disorder into remission. Discover tips for beginners & pros on diet, lifestyle & wellness.

Read more

Red Meat vs Plants: The Science Behind the Headlines
Podcast

Red Meat vs Plants: The Science Behind the Headlines

In this episode, Dr. Bret Scher examines two recent studies and highlights key limitations in their observational data, arguing that overall diet quality, calorie intake, lifestyle, and metabolic health may tell us far more than simply labeling meat as “bad” and plants as “good.”

Learn more

Beyond Ultra-Processed Foods: Why Macronutrients Matter
Perspectives in Metabolic Psychiatry

Beyond Ultra-Processed Foods: Why Macronutrients Matter

The question of whether most ultra-processed foods are metabolically harmful is no longer up for debate. This food category, which includes some of the most obvious dietary offenders…

Learn more

GLP-1 and Ketosis: Novel Mental Health Treatments
Podcast

GLP-1 and Ketosis: Novel Mental Health Treatments

Can weight-loss drugs help the brain? In this Metabolic Mind episode, Dr. Bret Scher interviews Dr. Roger McIntyre—Professor of Psychiatry and Pharmacology at the University of Toronto—about GLP-1 receptor agonists (e.g., Wegovy, Ozempic) and ketogenic therapy in mood disorders. Dr. McIntyre explains why psychiatry’s spotlight is moving from simple neurotransmitter theories to brain energy and cellular metabolism, and how GLP-1s might aid mood both indirectly (better metabolic health) and directly (GLP-1 action in brain circuits). He draws parallels with nutritional ketosis, noting overlapping effects on inflammation, insulin signaling, mitochondria, and neural networks. While optimistic, he stresses staying within current GLP-1 indications and building high-quality clinical trials for both medications and keto before broad psychiatric adoption. The takeaway: a future of “brain-protective” care that integrates meds, diet, sleep, exercise, and psychotherapy—shifting treatment toward resilience and offering real hope for people with depression and bipolar disorder.

Learn more

Find Your Keto
Resources

Find Your Keto

Explore metabolic therapies with Steven who put his bipolar 2 disorder into remission. Discover tips for beginners & pros on diet, lifestyle & wellness.

Read more

Red Meat vs Plants: The Science Behind the Headlines
Podcast

Red Meat vs Plants: The Science Behind the Headlines

In this episode, Dr. Bret Scher examines two recent studies and highlights key limitations in their observational data, arguing that overall diet quality, calorie intake, lifestyle, and metabolic health may tell us far more than simply labeling meat as “bad” and plants as “good.”

Learn more

Beyond Ultra-Processed Foods: Why Macronutrients Matter
Perspectives in Metabolic Psychiatry

Beyond Ultra-Processed Foods: Why Macronutrients Matter

The question of whether most ultra-processed foods are metabolically harmful is no longer up for debate. This food category, which includes some of the most obvious dietary offenders…

Learn more

GLP-1 and Ketosis: Novel Mental Health Treatments
Podcast

GLP-1 and Ketosis: Novel Mental Health Treatments

Can weight-loss drugs help the brain? In this Metabolic Mind episode, Dr. Bret Scher interviews Dr. Roger McIntyre—Professor of Psychiatry and Pharmacology at the University of Toronto—about GLP-1 receptor agonists (e.g., Wegovy, Ozempic) and ketogenic therapy in mood disorders. Dr. McIntyre explains why psychiatry’s spotlight is moving from simple neurotransmitter theories to brain energy and cellular metabolism, and how GLP-1s might aid mood both indirectly (better metabolic health) and directly (GLP-1 action in brain circuits). He draws parallels with nutritional ketosis, noting overlapping effects on inflammation, insulin signaling, mitochondria, and neural networks. While optimistic, he stresses staying within current GLP-1 indications and building high-quality clinical trials for both medications and keto before broad psychiatric adoption. The takeaway: a future of “brain-protective” care that integrates meds, diet, sleep, exercise, and psychotherapy—shifting treatment toward resilience and offering real hope for people with depression and bipolar disorder.

Learn more