Linking Mitochondrial Dysfunction, Neurotransmitter, and Neural Network Abnormalities and Mania: Elucidating Neurobiological Mechanisms of the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder

New Results: First RCT for Schizophrenia & Bipolar Disorder. Learn more.

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Reviews

Linking Mitochondrial Dysfunction, Neurotransmitter, and Neural Network Abnormalities and Mania: Elucidating Neurobiological Mechanisms of the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder

This review paper describes recent findings, highlighting 2 types of neurobiological abnormalities in BD: 1) mitochondrial dysfunction and 2) neurotransmitter and neural network functional abnormalities.

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Reviews

Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar Depression Medically Supervised Ketogenic Diet as an Adjunctive Treatment for Moderate to Severe Depression: A Pilot Study

Lamotrigine treats both epilepsy and bipolar disorder via shared neurobiology. This review explores whether therapeutic ketosis may synergistically enhance mood stabilization and metabolic health.

Reviews

The Ketogenic Diet for Depression and Anxiety: Implications for Practice

This review suggests low-carbohydrate and ketogenic diets show clinical potential for reducing depressive and anxiety symptoms as adjunctive therapies for treatment-resistant mental health conditions.

Reviews

A Retrospective Evaluation of an Online Group Ketogenic Metabolic Therapy Intervention on Mental Health Outcomes

This retrospective study found a 12-week remote ketogenic metabolic therapy program feasible and associated with reduced depression and anxiety symptoms in adults with varying mental health conditions.