Mechanisms of Insulin Resistance, Mitochondrial Dysfunction and the Action of the Ketogenic Diet in Bipolar Disorder

New Results: First RCT for Schizophrenia & Bipolar Disorder. Learn more.

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Reviews

Mechanisms of Insulin Resistance, Mitochondrial Dysfunction and the Action of the Ketogenic Diet in Bipolar Disorder

Drs. Harry and Iain Campbell suggest that mitochondrial dysfunction in bipolar disorder likely stems from issues with the Pyruvate Dehydrogenase Complex (PDC), leading to reduced energy production (ATP). This reduction could underlie BD’s mood instability, with the researchers proposing that ketogenic diets may stabilize mood by providing ketones as an alternative energy source.

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Reviews

Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar Depression Medically Supervised Ketogenic Diet as an Adjunctive Treatment for Moderate to Severe Depression: A Pilot Study

Lamotrigine treats both epilepsy and bipolar disorder via shared neurobiology. This review explores whether therapeutic ketosis may synergistically enhance mood stabilization and metabolic health.

Reviews

Ketogenic Therapy as a Potential Novel Treatment Approach for PTSD: An Integrative Review and Proposed Mechanistic Model

This integrative review of 16 studies suggests ketogenic therapies targeting brain metabolic pathways may improve PTSD, though robust human clinical trials remain lacking.

Reviews

A Retrospective Evaluation of an Online Group Ketogenic Metabolic Therapy Intervention on Mental Health Outcomes

This retrospective study found a 12-week remote ketogenic metabolic therapy program feasible and associated with reduced depression and anxiety symptoms in adults with varying mental health conditions.