The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review

New Results: First RCT for Schizophrenia & Bipolar Disorder. Learn more.

Peers & Families

Learn how metabolic health could play a powerful role in mental health recovery. Whether you're supporting a loved one or navigating your own path, this space offers practical insights and hope.
Overview
Navigate Your Care
Find Your People
For Clinicians

Reimagine treatment by exploring tools to integrate metabolic therapies into your practice and learn how to use ketogenic interventions as first-line or adjunctive options to improve outcomes in serious mental illness.
Overview
Training & Education
Science

Explore our curated database of peer-reviewed literature connecting metabolic and mental health. Browse active and published clinical trials of ketogenic therapy for psychiatric conditions, and learn from interviews with pioneering scientists.
Overview
Clinical Evidence
Active Trials
Research Database
Resources

Access curated resources to stay informed and take action, from scientific summaries to clinical evidence to videos, podcasts and more. Whether you're tracking research or exploring topics, these tools are here to help.
Overview
Topics by Diagnosis
Special Topics
Curated Picks
News
Episodes
Blog
THINK + SMART

THINK+SMART is a free, self-guided program that helps you explore ketogenic and lifestyle strategies for mental health, offering science-backed tools and lived experience to support personalized healing.
Overview
Stories & Strategies
Share Your Story
THINK + SMART FAQ
Get Started
About Us

We envision a future in which the metabolic health of every individual is assessed and addressed with evidence-based interventions, leading to improved mental and physical health for all.”
- Jan Baszucki Founder, Metabolic Mind
Our Story
Our Team
Contact
Awards
Metabolic Mind FAQ
Subscribe

Reviews

The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review

Drs. Shebani Sethi and Judy Ford call for more clinical trials to address the potential beneficial effects of the ketogenic diet in people with serious mental illness.

Continue reading:

Reviews

Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar Depression Medically Supervised Ketogenic Diet as an Adjunctive Treatment for Moderate to Severe Depression: A Pilot Study

Lamotrigine treats both epilepsy and bipolar disorder via shared neurobiology. This review explores whether therapeutic ketosis may synergistically enhance mood stabilization and metabolic health.

Reviews

A Retrospective Evaluation of an Online Group Ketogenic Metabolic Therapy Intervention on Mental Health Outcomes

This retrospective study found a 12-week remote ketogenic metabolic therapy program feasible and associated with reduced depression and anxiety symptoms in adults with varying mental health conditions.

Reviews

Metabolic Plasticity: An Evolutionary Perspective on Metabolic and Circadian Dysregulation in Bipolar Disorder

This perspective review examines bipolar disorder through a metabolic lens. It highlights how nutrition, seasonal light, and metabolic shifts may contribute to symptom instability.