Metabolic Plasticity: An Evolutionary Perspective on Metabolic and Circadian Dysregulation in Bipolar Disorder

First Ketogenic Therapy for Anorexia Nervosa Trial. Learn more.

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Reviews

Metabolic Plasticity: An Evolutionary Perspective on Metabolic and Circadian Dysregulation in Bipolar Disorder

This perspective review examines bipolar disorder through a metabolic lens. It highlights how nutrition, seasonal light, and metabolic shifts may contribute to symptom instability.

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Reviews

Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar DepressionMedically Supervised Ketogenic Diet as an Adjunctive Treatment for Moderate to Severe Depression: A Pilot Study

Lamotrigine treats both epilepsy and bipolar disorder via shared neurobiology. This review explores whether therapeutic ketosis may synergistically enhance mood stabilization and metabolic health.

Reviews

A Retrospective Evaluation of an Online Group Ketogenic Metabolic Therapy Intervention on Mental Health Outcomes

This retrospective study found a 12-week remote ketogenic metabolic therapy program feasible and associated with reduced depression and anxiety symptoms in adults with varying mental health conditions.

Reviews

The Ketogenic Diet for Depression and Anxiety: Implications for Practice

This review suggests low-carbohydrate and ketogenic diets show clinical potential for reducing depressive and anxiety symptoms as adjunctive therapies for treatment-resistant mental health conditions.