Pilot study of a ketogenic diet in bipolar disorder
In this study, Drs. Daniel Smith, Nicole Needham, Iain Campbell, and colleagues evaluated the use of ketogenic therapy in bipolar disorder.
Scientific papers
Treating Insulin Resistance With Metformin as a Strategy to Improve Clinical Outcomes in Treatment-Resistant Bipolar Depression
In this study, Dr. Cynthia Calkin and colleagues demonstrated that treating patients with metformin, a diabetes medication, significantly improved bipolar disorder symptoms. Since metformin’s primary effect is improving liver insulin resistance, this study strongly suggests that treating insulin resistance directly improves symptoms of Bipolar Disorder.
The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review
In this review article, Drs. Shebani Sethi and Judith Ford review the evidence supporting the use of ketogenic diets for mental illness.
Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients
In his inpatient practice, Dr. Albert Danan treated 31 patients with refractory mental illness with a ketogenic diet. Of the 28 who stayed on the diet, all had improved symptoms. More than forty percent went into clinical remission, and more than half were able to reduce their medications. This paper elucidates the power of inpatient dietary treatment for helping people with treatment-resistant serious mental illnesses.
Ketogenic Therapy in Serious Mental Illness: Emerging Evidence
In this commentary, Drs. Chris Palmer and Zoltan Sarnyai review the emerging evidence supporting the use of nutritional ketosis as a treatment for serious mental illness.